Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: A case-control study
Identifieur interne : 001331 ( Main/Exploration ); précédent : 001330; suivant : 001332Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: A case-control study
Auteurs : Cristina García-Delaney [Espagne] ; Maria-Ángeles Sánchez-Garcés [Espagne] ; Rui Figueiredo [Espagne] ; Alba Sánchez-Torres [Espagne] ; Cosme Gay-Escoda [Espagne]Source :
- Medicina Oral, Patología Oral y Cirugía Bucal [ 1698-4447 ] ; 2015.
Abstract
Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients.
A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.
The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (
IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.
Url:
DOI: 10.4317/medoral.20655
PubMed: 26449434
PubMed Central: 4670255
Affiliations:
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as a predictor of peri-implantitis: A case-control study</title><author><name sortKey="Garcia Delaney, Cristina" sort="Garcia Delaney, Cristina" uniqKey="Garcia Delaney C" first="Cristina" last="García-Delaney">Cristina García-Delaney</name><affiliation wicri:level="1"><nlm:aff id="A1">DDS. Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS. Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Sanchez Garces, Maria Ngeles" sort="Sanchez Garces, Maria Ngeles" uniqKey="Sanchez Garces M" first="Maria-Ángeles" last="Sánchez-Garcés">Maria-Ángeles Sánchez-Garcés</name><affiliation wicri:level="3"><nlm:aff id="A2">MD, DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>MD, DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Figueiredo, Rui" sort="Figueiredo, Rui" uniqKey="Figueiredo R" first="Rui" last="Figueiredo">Rui Figueiredo</name><affiliation wicri:level="3"><nlm:aff id="A3">DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Sanchez Torres, Alba" sort="Sanchez Torres, Alba" uniqKey="Sanchez Torres A" first="Alba" last="Sánchez-Torres">Alba Sánchez-Torres</name><affiliation wicri:level="1"><nlm:aff id="A4">DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gay Escoda, Cosme" sort="Gay Escoda, Cosme" uniqKey="Gay Escoda C" first="Cosme" last="Gay-Escoda">Cosme Gay-Escoda</name><affiliation wicri:level="3"><nlm:aff id="A5">MD, DDS, MS, PhD, Chairman and Professor of Oral and Maxillofacial Surgery, School of Dentistry, Barcelona. Director of the Master`s Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department of the Teknon Medical Center, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>MD, DDS, MS, PhD, Chairman and Professor of Oral and Maxillofacial Surgery, School of Dentistry, Barcelona. Director of the Master`s Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department of the Teknon Medical Center, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">Medicina Oral, Patología Oral y Cirugía Bucal</title><idno type="ISSN">1698-4447</idno><idno type="eISSN">1698-6946</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients.</p></sec><sec><title>Material and Methods</title><p>A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.</p></sec><sec><title>Results</title><p>The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (<italic>p</italic>=0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found.</p></sec><sec><title>Conclusions</title><p>IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.</p><p><bold>Key words:</bold>Peri-implantitis, interleukin-1 genotype positive, case-control study, smoking.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey=" Cosyn, J" uniqKey=" Cosyn "> J Cosyn </name></author><author><name sortKey=" Christiaens, V" uniqKey=" Christiaens "> V Christiaens </name></author><author><name sortKey=" Koningsveld, V" uniqKey=" Koningsveld "> V Koningsveld </name></author><author><name sortKey=" Coucke, Pj" uniqKey=" Coucke "> PJ Coucke </name></author><author><name sortKey=" De Coster, P" uniqKey=" De Coster "> P De Coster </name></author><author><name sortKey=" De Paepe, A" uniqKey=" De Paepe "> A De Paepe </name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liao, J" uniqKey="Liao J">J Liao</name></author><author><name sortKey="Li, C" uniqKey="Li C">C 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first="Cosme" last="Gay-Escoda">Cosme Gay-Escoda</name><name sortKey="Sanchez Garces, Maria Ngeles" sort="Sanchez Garces, Maria Ngeles" uniqKey="Sanchez Garces M" first="Maria-Ángeles" last="Sánchez-Garcés">Maria-Ángeles Sánchez-Garcés</name><name sortKey="Sanchez Torres, Alba" sort="Sanchez Torres, Alba" uniqKey="Sanchez Torres A" first="Alba" last="Sánchez-Torres">Alba Sánchez-Torres</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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